유전자(DNA) 계절 탄다는 연구 논문
(강직성척추염, 류마티스 환우 관심 가져야 할 듯)
*** 겨울철에 유전자 반응 활발…빛, 온도가 생체시계에 영향 주는 듯
☞ 참고 한국생명공학연구원
※실제 연구팀이 규명한 유전자의 계절별 반응 결과는 겨울철에 심장병이나 류마티스관절염이 많이 발생하는 원인에 대한 연구로 이어질 수 있습니다.※
본인이 항상 말씀드리는 이유가 연구 논문으로 발표되었네요.
강직성척추염 환우들은 ①겨울철, ②여름철, ③습도 높은 날, ④비오는 날, ⑤비오기 전 날, ⑥온도의 급격한 변화 등에 『신경근과 근육의 이상으로 경직과 통증이 생긴다는 말이 아래의 연구논문으로 증명』을 하고 있습니다.
우리 몸속에 있는 유전자(Gene)도 계절을 타는 것으로 연구 결과 밝혀졌습니다.
날씨가 변하듯이 우리 몸속의 유전자도 계절에 따라 영향을 받는다는 것이죠.
이는 특정 시기에 나타나는 질병과의 연관성을 밝혀낼 수 있어 관심을 모으는 부분입니다.
영국 캠브리지 대학의 크리스 월리스 면역유전학자는 이 같은 연구 결과를 네이처커뮤니케이션즈에 발표하면서 "우리 몸속의 유전자는 계절이 바뀌는 것을 감지한다"고 설명했습니다.
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)
◀유전자도 계절을 타는 것으로 조사됐다. 이중 나선구조의 DNA.
[사진제공=한국생명공학연구원]
◆오묘한 우리 몸의 구조 = DNA(Deoxyribonucleic acid, 디옥시리보핵산)라는 말은 많이 들어보셨을 겁니다. 유전물질을 말합니다. 이중 나선구조로 돼 있죠. 사실 DNA가 유전물질이라는 것을 알기까지 인류는 많은 노력과 연구가 필요했지요.
그 다음 유전자(Gene)가 있습니다.
유전자는 DNA 전체가 아니고 특정한 단백질을 합성하는 정보를 가진 디옥시뉴클레오티드의 묶음을 말합니다. 상당히 중요한 존재입니다.
유전자에 이상이 발생했을 때 특정 단백질 형성에 영향을 주기 때문에 이른바 '유전병'이 일어나게 됩니다.
게놈(Genome)은 유전 정보의 총합을 말합니다. 영국 정부에서 현재 '10만 게놈 프로젝트'를 추진하고 있죠. 특정 암환자 등의 유전 정보의 총합을 규명해 암 등 특정 질병 예방에 나서겠다는 거대 프로젝트입니다. 인간의 유전 정보의 전체를 밝히겠다는 것이죠.
◆계절 타는 유전자 = 단백질 형성에 관여하는 유전자가 계절을 탄다는 연구 결과를 이제 살펴보겠습니다.
캠브리지 대학 연구팀은 독일, 호주, 미국, 영국, 아이슬란드, 잠비아 등 6개 국가의 1000명이 넘는 사람의 DNA를 조사했습니다.
유전자는 면역체계에 관여하는데 특히 특정 염증에 대처하는 경우 겨울철에 면역 시스템이 훨씬 활발하게 작동하는 것으로 밝혀졌습니다.
겨울철에 염증성 질환이 발생하면 혈액 속에 있는 유전자가 풀리면서 메신저를 통해 단백질 형성을 위한 청사진 코드를 보내게 됩니다.
이런 방어 시스템으로 추운 겨울날 발생할 수 있는 질병으로부터 우리 몸을 보호한다는 것이죠.
겨울철은 밤이 아주 깁니다. 태양이 사라지고 비구름이 하늘을 뒤덮기도 하죠. 이때 수조개의 T세포가 감기와 독감 등과 싸우기 위해 몸속에 생성된다는 겁니다.
연구 결과를 보면 혈액 속에 있는 전체 유전자의 5분의1 이상이 계절 변화에 반응한다고 합니다. 이런 계절별 변화는 고혈압, 자기면역 질병, 1형 당뇨병과 같은 질환에 대한 실마리를 제공해 줄 수 있을 것으로 기대됩니다.
◆6개국 1000명 이상 관찰
= 우리 몸속의 모든 세포에는 같은 유전자 코드를 가지고 있습니다.
특별한 상황에서 이 유전자가 풀려나게 되고 이 유전자는 메신저인 RNA에 노출됩니다.
RNA는 유전자가 만든 코드를 집어 들고 단백질을 만드는 과정을 시작하게 되는 것이죠.
연구 결과 혈액 세포 속에 있는 약 5000개의 유전자가 계절의 변화에 따라 변한다는 것이 밝혀졌습니다.
윌리스 교수는 "염증은 인간에게 해를 끼친다"며 "특히 겨울철에는 염증에 더욱 민감하게 반응한다"고 설명했습니다.
적도 지역에 위치해 있는 잠비아의 경우는 조금 특별했습니다. 잠비아는 겨울이 없기 때문이죠. 대신 잠비아의 경우 말라리아가 극성을 부리는 우기 때 염증 질병이 많아진다는 것을 밝혀냈습니다. 또 이때 유전자가 계절에 민감하게 반응한다는 것이 드러났습니다.
이런 유전자의 계절별 반응 변화는 왜 일어나는 것일까요.
윌리스 교수는 아직 단정적으로 말할 수는 없다고 밝혔습니다.
집안에 머무는 시간이나 먹는 음식의 차이 등 생활 습관에 따른 변화일 수도 있다고 합니다.
윌리스 교수는 아마도 환경적 변화가 가장 큰 원인일 것으로 짐작하고 있습니다. 예를 들어 낮 시간의 길이가 영향을 끼칠 수 있다는 것이죠. 즉 빛이 생체 시계에 영향을 끼쳐 유전자가 조절 받는다는 겁니다. 온도 변화도 하나의 요인일 수 있다고 판단하고 있습니다.
윌리스 교수는 "유전자가 계절 변화에 민감하게 반응하는 원인에 대해 명확한 결론을 내릴 수는 없다"고 전제하면서
"분명한 것은 환경이 변하게 되면 이 변화에 조화를 맞추기 위해 유전자도 적응하게 되는 것"이라고 설명했습니다.
◆특정 질병 출현에 실마리 제공
= 이번 연구는 특정 질병에 대한 출현 시기를 예상할 수 있는 실마리를 제공할 수 있을 것으로 기대됩니다. 전자가 계절에 민감하게 반응하고 면역 시스템과 관련이 있다면 특정 질병이 많이 발생하는 시기와 일치할 수 있기 때문입니다.
실제 연구팀이 규명한 유전자의 계절별 반응 결과는 겨울철에 심장병이나 류마티스관절염이 많이 발생하는 원인에 대한 연구로 이어질 수 있습니다.
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